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DNA polymerase epsilon, encoded by the POLE gene, is a critical protein involved in DNA proofreading and replication. 1 POLE synthesizes the leading strand of DNA in the replication fork and has a 3′-5′ exonuclease domain that increases replication accuracy by approximately 100-fold through recognition and excision of mismatched base pairs. 2,3 Somatic and germline POLE ...
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